Anti-infective activities of secondary metabolites from Vitex pinnata

Nurkhalida, Kamal and Ruangelie, Edrada-Ebel and Carol, Clements (2016) Anti-infective activities of secondary metabolites from Vitex pinnata. Journal of Applied Pharmaceutical Science, 6 (1). pp. 102-106. ISSN 22313354 [P]

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Abstract

The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids く-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5- hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1- 4 showed moderate antitrypanosomal activity with MIC values of 6.25たg/ml, 19.0, 21.0 and 17.0たM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.

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