The Free Alpha-Hemoglobin: A Promising Biomarker for β-Thalassemia

Uday Younis, Hussein and Ahmed Ghazi, Faisal and Atif, Amin Baig (2014) The Free Alpha-Hemoglobin: A Promising Biomarker for β-Thalassemia. Molecular Biomarkers & Diagnosis, 5 (5). pp. 1-7. ISSN 2155-9929

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Abstract

The purpose is to review the current knowledge and methods of determination of the free alpha hemoglobin with emphasis on its potential implications in patients with beta-thalassemia (β-thal).The severity of β-thal correlates with the extent of imbalance between α- and non-α-globin chains and the amount of the free alpha hemoglobin (free α- Hb) pool in the erythrocytes. To date, there is a lack of biomarkers that convey diagnostic and prognostic values in β-thal. Our ongoing research is aimed to evaluate the potential prognostic and diagnostic implications of free α-Hb to improve the care of patients with β-thal. Our ongoing research is aimed to quantify the free α-Hb for its potential prognostic and diagnostic implications towards improving the care of patients with various β-thal types in the years to come.

Item Type: Article
Uncontrolled Keywords: Free alpha haemoglobin; Biomarker; Beta-thalassemia; Alpha globin gene; Alpha globin chain; Malaysia
Subjects: Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Health Sciences
Depositing User: Rafidah Saaid
Date Deposited: 17 Jan 2022 07:38
Last Modified: 17 Jan 2022 07:38
URI: http://eprints.unisza.edu.my/id/eprint/4756

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