Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity

Abd Manaf, Ali (2012) Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity. Evidence-based Complementary and alternative medicine. ISSN 1741427X

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Abstract

The in vivo immunomodulatory effect of ethanolic extracts from leaves of Rhaphidophora korthalsii was determined via immune cell proliferation. T/NK cell phenotyping. and splenocyte cytotoxicity of IBALS/c mice after 5 consecutive days of i p administration at various concentrations Spenocyte proliferation index. cytotoxicity penpheral blood TrNK cell population and plasma cytokine (IL-2 and IFII-y) in mice were assessed on day 5 and day 15. High concentration of extract (35Oug/mice/day for 6 consecutive days) was able to stimulate immune cell proliferation. peripheral blood NK cell population. IL-2 and IFN-v cytokines. as well as splenocyte cytotoxicity against Vac-1 cell line Unlike it-2 which degraded rapidly the stimulatory effect from the extract managed to last until day 15 These results suggested the potential of this extract as an attemative immunostimulator. and they encourage further study on guided fractionation and purification to identify the active ingredients that contribute to this in vitro and in vivo immunomodulatory activity Copyright 0 2012 Swee Keong Yeap et al

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