Identification of a dietary pattern associated with lower high molecular weight adiponectin in breast cancer survivors

Mohd Razif, Shahril and Nor Syamimi, Zakarai and Geeta, Appannah and Aryati, Ahmad and Hamid JanJan, Mohamed (2019) Identification of a dietary pattern associated with lower high molecular weight adiponectin in breast cancer survivors. In: Asian Congress of Nutrition 2019, 4-7 August 2019, Bali, Indonesia.

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Abstract

Background/Aims: Energy dense, high saturated fat, low fibre diets may contribute to obesity in breast cancer survivors, how-ever their relationships with high molecular weight (HMW) adi-ponectin are unclear. We examined associations between an 'en-ergy-dense, high saturated fat and low-fibre' dietary pattern (DP) and HMW adiponectin in breast cancer survivors. Methods: Data was obtained from 96 participants in the East Coast of Peninsular Malaysia Breast Cancer Survivors Study. Dietary intake, anthropo-metric and 1-IMW adiponectin were measured and z-scores for an 'energy dense, high saturated fat and low fibre' DP were estimated using reduced rank regression (RRR). Associations between DP z-scores and IIMW adiponectin were examined using regression models. Results: The results of this study show that, a 1 unit in-crease in DP z-score was associated with a 0.41 Rg/mL lower HMW adiponectin (95% CI: —0.806, —0.014) independently of age, BMI, cancer stage, duration since diagnosis, education level and occupa-tion status. The 'energy dense, high saturated fat and low fibre' DP which was characterized by high intake of sugar sweetened bever-ages and fat-based spread while lower intake of fruits and vegeta-bles were further examined to find which food groups contributed significantly to the association. Interestingly no significant find-ings were found supporting that totality of the diet provides more accurate description of actual dietary exposure. Conclusion: As a conclusion, 'energy dense, high saturated fat, low fibre' DP is neg-atively associated with HMiA, adiponectin. This finding could serve as a basis in examining the relationship between dietary ex-posure, obesity and cancer survivorship.

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