Glucose metabolism: the energy-producing metabolic pathways in human spermatozoa motility

Nurul Fadhlina, Ismail (2020) Glucose metabolism: the energy-producing metabolic pathways in human spermatozoa motility. Asian Journal of Medicine and Biomedicine, 4 (SI 1). pp. 47-51. ISSN 2600-8173

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Abstract

After ejaculation, human spermatozoa must undergo various cellular processes, for egg fertilization. Glycolysis and oxidative phosphorylation (OXPHOS) are the some of metabolic pathways to produce energy in form of Adenosine triphosphate (ATP). Several studies suggest that spermatozoa have the ability to switch between these pathways. However, there is a debate in determine which pathways is a dominant energy producing pathway particularly for motility process. Therefore, this review intends to present a general overview of the current knowledge of the energy-producing metabolic pathways operating inside human spermatozoa and the choice of the pathways to produce ATP. Metabolism of glucose is critically reviewed. Such knowledge, aparts from its added knowledge for basic science, could eventually translate into the development of novel strategies for treatment of male infertility.

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