Screening Of bismillah leaf (Vernonia Amygdalina) extraction for antiproliferative activies in human glioblastoma brain cancer cell lines

Mohd Adzim Khalili, Rohin and Napisah, Hussin and Norhayati, Abd. Hadi (2016) Screening Of bismillah leaf (Vernonia Amygdalina) extraction for antiproliferative activies in human glioblastoma brain cancer cell lines. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (2). pp. 1084-1089. ISSN 09758585 [P]

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Abstract

Vernonia amygdalina is a member of the Asteraceae family. It is a shrub or small tree that can reach up to 10 m in height and with a trunk diameter reaching up to 40 cm. The plant is a vegetable in its native land and is put through a detoxification process before it is cooked as food. The process involves boiling the leaves several times while changing the water after each cycle until the bitterness disappears. This study was carried out to screen the ethanol, methanol and ethyl acetate extracts of Vernonia Amygdalina as an anti-proliferative agent that inhibits the growth of human glioblastoma brain cancer cell lines (U-87). The anti-proliferative study indicated that only ethyl acetate extracts from Vernonia amygdalina were found to be cytotoxic towards U-87 cancer cell lines with an IC50 value of 18.80 ± 1.11 µg/ml. There was no IC50 value for ethanol and methanol extracts from Vernonia amygdalina. Thus, ethyl acetate extracts from Vernonia amygdalina could be envisaged for further exploration in efforts to develop newer and safer cytotoxic compounds.

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