No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males

Nasir, Mohamad and Zalina, Zahari and Chee Siong, Lee (2015) No Association of Polymorphisms in the Dopamine Receptor D2 (DRD2) Gene with Cold Pressor Pain Sensitivity among Healthy Malay Males. PUBLIC HEALTH GENOMICS, 18. pp. 30-31. ISSN 1662-4246

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Abstract

Objective: To examine the effects of variations of loci in the dopamine receptor D2 (DRD2) gene on cold pressor pain responses among healthy Malay males. Material and Methods: Healthy Malay males (n = 152) from a local population signed an informed-consent and participated in this study. Their cold pressor test (CPT) responses (pain threshold, pain tolerance and pain intensity) were assessed at 0 hour, and at 2, 4, 8, 12, and 24 hours after the first CPT. DNA was extracted from whole blood and subjected to PCR-genotyping for eight DRD2 polymorphisms (Val96Ala, Leu141Leu, Val154Ile, Pro310Ser, Ser311Cys, TaqI A, −141C Ins/Del and A-241G). The differences of CPT responses between the DRD2 polymorphisms were analysed using repeated measure ANOVA (RM-ANOVA). Results: Val96Ala, Leu141Leu, Val154Ile and Pro310Ser polymorphisms were not detected in any subject. There were no significant differences in pain responses (pain threshold, tolerance and intensity) between Ser311Cys, TaqI A, −141C Ins/Del and A-241G polymorphisms of DRD2 gene. Conclusion: DRD2 polymorphisms do not have impact on cold pressor pain threshold, pain tolerance and pain intensity. The present results also do not support the notion that DRD2 polymorphisms play a major role in cold pressor pain sensitivity.

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