Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis

Azmahani, Abdullah and Yasuhiro, Nakamura and Hirotaka, Ishida (2017) Estrogen receptors in merkel cell carcinoma: Its possible roles in pathogenesis. Research Journal of Pharmacy and Technology, 10 (12). pp. 27-28. ISSN 0974-3618

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Abstract

Sex steroids have been postulated to influence skin development and functions as well as its pathogenesis. Merkel cell carcinoma (MCC) occurs in both genders however, the specific differences in pathogenesis amongst genders have yet to be conclusively defined. The detailed status of sex steroid receptors (androgen receptor (AR), progesterone receptor (PR) A and PRB, and estrogen receptor (ER) a, ERß) are also unknown in Merkel cell carcinoma (MCC) patients. We first immunolocalized sex steroid receptors and compared the results with immunolocalization of relevant transcription factors including SOX2, forkhead box protein A1 (FOXA1) and Bcl-2 and Ki-67 in 14 cases of MCCs. AR, PRA, PRB, ERa, ERß, Bcl-2, SOX2 and FOXA1 immunoreactivity was evaluated by employing the modified H-score method and Ki-67 were quantified using labeling index (LI%). ERß immunoreactivity was markedly present in all the cases of MCC examined with relatively weak immunoreactivity of ERa, AR and PRA. The status of ERß immunoreactivity was also significantly correlated with Ki67 LI and Bcl-2 score. These results demonstrated that ERß could be associated with regulation of both cell proliferation and apoptosis in MCCs.

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