Hisham Saleh, Ibrahim and Gabrielle Ruth Anisah, Froemming and Effat, Omar (2014) ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats. Reproductive Toxicology, 49. pp. 155-161. ISSN 08906238
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Abstract
This study investigates the effect of ACE2 activation on leptin-induced changes in systolic blood pressure (SBP), proteinuria, endothelial activation and ACE2 expression during pregnancy in Sprague-Dawley rats. Pregnant rats were given subcutaneous injection of either saline, or leptin, or leptin plus xanthenone (ACE2 activator), or xanthenone (XTN) alone. SBP, serum ACE, ACE2, endothelin-1, E-selectin and ICAM-1 levels were estimated; also their gene expressions were determined in the kidney and aorta respectively. Compared to control, SBP was higher in the leptin-only treated group (P<0.001) and lower in rats treated with xanthenone alone (P<0.01). Proteinuria, markers of endothelial activation were significantly higher than controls in leptin-only treated rats (P<0.05). ACE2 activity and expression were lower in leptin-only treated rats when compared to controls (P<0.05). It seems, leptin administration during pregnancy significantly increases SBP, proteinuria, endothelial activation, but decreases ACE2 level and expression. These effects are prevented by concurrent administration of xanthenone.
Item Type: | Article |
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Uncontrolled Keywords: | ACE2; Blood pressure; E-selectin; Endothelial activation; Endothelin-1; ICAM-1; Leptin; Proteinuria. |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Health Sciences |
Depositing User: | Syahmi Manaf |
Date Deposited: | 13 Sep 2022 04:23 |
Last Modified: | 13 Sep 2022 04:23 |
URI: | http://eprints.unisza.edu.my/id/eprint/5543 |
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