Role Of Leptin, FTO and VEGF Genes In Adipogenesis Derived Angiogenesis

Kamal, Akhtar and Mehwish, K and Aaliya, S (2014) Role Of Leptin, FTO and VEGF Genes In Adipogenesis Derived Angiogenesis. Bulletin of the Genetics Society of Malaysia, 2 (1). pp. 60-65. ISSN 1394-5750

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Abstract

Obesity is a disease caused by the accumulation of excess body fat mass which possesses adverse effects on health and leads to development of various diseases such as hypertension, cardiovascular diseases, type 2 diabetes and etc. (Ministry of Health Malaysia, 2004).Obesity is a severe issue facing most developed nations and many other emerging economies with the World Health Organization (WHO) estimating that there will be over 2 billion overweight and 700 million obese adults in the world by 2015 (WHO, 1997).Hence, obesity has raised alarming concerns internationally. In this new generation, the rate of obesity has tremendously been increasing due to poor lifestyle and eating habits such as high intake of high fat diet and junk foods. According to WHO, obesity has almost doubled since 1980 worldwide (WHO, 2000). Obesity is a result of interplay between genetic and environmental factors. The risk of obesity is determined not only by specific genotypes but also by certain gene-gene interactions Friedman, 2000). As per the Malaysia society of obesity in 2013, obesity disease is highlighted as the root cause of many other associated diseases (Roth et al., 2004).It has been reported that there were around three million obese Malaysians and the number is increasing tremendously and among them there were about five millions individuals who are suffering from type 2 or gestational diabetes ( Korner and Aronne, 2003).The most basic determinant of excess weight is due to the imbalance between calories consumed and calories burnt.

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