Reasons of Unknown HPLC Peaks during Hemoglobin Analysis for Patients with Beta Thalassemias

Uday Younis, Hussein and Ahmed Ghazi, Faisal (2014) Reasons of Unknown HPLC Peaks during Hemoglobin Analysis for Patients with Beta Thalassemias. Journal of Hematology & Thromboembolic Diseases, 2 (5). pp. 1-2. ISSN 2329-8790

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Abstract

Beta-thalassemias (β-thal) are inherited quantitative disorders of haemoglobin (Hb) leading to underproduction of the beta globin chains of hemoglobin. In β-thal, the synthesis of normal α globin chains from the unaffected α globin gene continues as normal, resulting in the accumulation within the erythroid precursors of excess free α globin chains, which precipitate in the red cell precursors in the bone marrow forming inclusion bodies. Excess free alpha globin chain precipitate as insoluble hemichrome on the inner surface of red cell membrane (membrane-bound), forming inclusions called micro- Heinz bodies or occure as free cytosolic (soluble) hemichrome.

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