Nurul Hikmah, Harun (2011) Inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants. Journal of natural medicine, 65 (1). pp. 400-405. ISSN 13403443
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Abstract
The methanol extracts of 20 selected medicinalplants were investigated for their effects on the respiratoryburst of human whole blood, isolated human polymorpho-nuclear leukocytes (PMNs) and isolated mice macrophagesusing a luminol/lucigenin-based chemiluminescence assay.We also tested the effect of the extracts on chemotacticmigration of PMNs using the Boyden chamber technique.The extracts ofCurcuma domesticaL.,Phyllanthus amarusSchum & Thonn andC. xanthorrhizaRoxb. were thesamples producing the strongest oxidative burst of PMNswith luminol-based chemiluminescence, with IC50valuesranging from 0.5 to 0.7lg/ml. For macrophage cells, theextracts which showed strong suppressive activity forluminol-based chemiluminescence wereC. xanthorrhizaandGarcinia mangostanaL.Among the extracts studied,C. manggaValton & Vazsjip, Piper nigrumL. andLabisiapumilavar.alatashowed strong inhibitory activity onlucigenin-amplified oxidative burst of PMNs, with IC50values ranging from 0.9 to 1.5lg/ml. The extracts ofZingiber officinaleRosc.,Alpinia galangal(L.) Willd andAverrhoa bilimbiLinn showed strong inhibition on thechemotaxic migration of cells, with IC50values compara-ble to that of ibuprofen (1.5lg/ml). The results suggestthat some of these plants were able to modulate the innateimmune response of phagocytes at different steps,emphasizing their potential as a source of new immuno-modulatory agents
Item Type: | Article |
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Uncontrolled Keywords: | Medicinal plants�Immunomodulatory effect�Polymorphonuclear leukocytes�Macrophage cells�Chemiluminescence�Chemotactic activit |
Subjects: | R Medicine > R Medicine (General) |
Divisions: | Faculty of Health Sciences |
Depositing User: | Mrs Norhidayah Razak |
Date Deposited: | 30 Nov 2020 07:08 |
Last Modified: | 15 Aug 2021 02:14 |
URI: | http://eprints.unisza.edu.my/id/eprint/2050 |
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